32 papers
Geriatric medicine focuses on the unique health needs of older adults, addressing complex conditions that often arise as we age. This field goes beyond treating single diseases to manage the whole person, considering how multiple chronic issues, medication interactions, and physical changes affect quality of life. By prioritizing functional ability and dignity, researchers in this space aim to help people live healthier, more independent lives for as long as possible.
Gist.Science makes the latest findings in this vital area accessible by processing every new preprint from medRxiv in this category. We transform these raw scientific reports into both plain-language overviews for general readers and detailed technical summaries for specialists, ensuring no one is left behind by complex jargon. Below are the latest papers in geriatric medicine, updated regularly as new research becomes available on medRxiv.
This study utilized untargeted plasma metabolomics to identify specific lipid and energy metabolism-related biomarkers associated with frailty in older adults at risk of dementia, revealing distinct temporal patterns of metabolite abundance that could serve as predictive indicators for early detection and intervention.
The PREACH study engaged over 1,000 UK care home stakeholders to identify research priorities centered on quality of life and meaningful activities, revealing a significant gap between these resident-focused needs and the disease-specific focus of existing research datasets.
This post hoc analysis of the ASPREE trial suggests that low-dose aspirin may improve disability-free survival specifically among a subset of US Black and Hispanic older adults with high predicted benefit, although these findings require external validation before guiding clinical practice.
This study involving 128 older adults reveals that instructions without visual cues are more acceptable for complex cognitive training games and that higher cognitive self-efficacy generally increases technology acceptance, highlighting the need for simple, personalized instructions to optimize engagement.
In a contemporary and diverse cohort, most established Alzheimer's disease risk algorithms showed limited discriminatory power for clinical and biomarker outcomes, but including a functional assessment measure significantly improved their ability to distinguish between healthy cognition, mild cognitive impairment, and Alzheimer's disease.
This comparative study of Spain, Italy, Chile, and Colombia reveals that while all four nations have established policy frameworks to address multimorbidity and frailty in rapidly aging populations, the primary challenge lies in overcoming implementation barriers such as fragmented services and workforce constraints to achieve effective health-social care integration.
This study of 5,042 NHANES adults reveals that the protective effect of physical activity against type 2 diabetes is significantly modified by both obesity and age, being strongest in normal-weight and middle-aged individuals while diminishing or disappearing in those with obesity or older age, thereby supporting the need for stratified prevention strategies.
This study demonstrates that while PET-anchored and distribution-based thresholds for plasma pTau-217 yield similar classifications at the extreme ends of the biomarker distribution, they diverge significantly in the intermediate range, suggesting that the choice of thresholding method rather than the analytical platform is the primary driver of positivity status and should be tailored to the specific clinical or research application.
This study utilizes a validated synthetic cohort of older Ghanaian adults to demonstrate that STOPP/START v3 criteria identify significantly higher rates of potentially inappropriate prescribing than the AGS Beers 2023 criteria, thereby establishing synthetic data modeling as a scalable, privacy-preserving solution for auditing medication safety in data-scarce sub-Saharan health systems.
This cross-sectional study of older adults in a Kazakhstani social-care institution reveals a double burden of malnutrition characterized by high rates of overweight, obesity, and cardiometabolic risk coexisting with widespread micronutrient deficiencies, particularly vitamin D, challenging the typical perception of undernutrition in residential care settings.