13 papers
Geriatric medicine focuses on the unique health needs of older adults, addressing complex conditions that often arise as we age. This field goes beyond treating single diseases to manage the whole person, considering how multiple chronic issues, medication interactions, and physical changes affect quality of life. By prioritizing functional ability and dignity, researchers in this space aim to help people live healthier, more independent lives for as long as possible.
Gist.Science makes the latest findings in this vital area accessible by processing every new preprint from medRxiv in this category. We transform these raw scientific reports into both plain-language overviews for general readers and detailed technical summaries for specialists, ensuring no one is left behind by complex jargon. Below are the latest papers in geriatric medicine, updated regularly as new research becomes available on medRxiv.
This study of older HIV-positive Veterans demonstrates that the VACS 2.0 Frailty Index correlates with medication burden and strongly associates with soluble TNF receptor levels, suggesting a potential link between systemic inflammation and frailty that warrants further mechanistic investigation.
This manuscript, which investigated the relationship between oxidative balance score and osteoarthritis using NHANES, RNA-seq, and Mendelian randomization, has been formally withdrawn by the authors due to a fundamental flaw in the study design where the reliance on unverified self-reported diagnoses introduced substantial misclassification bias that invalidates the core findings.
This pilot study demonstrates that replacing 16 to 26 liters of blood plasma in patients with mild cognitive impairment and Alzheimer's biomarkers with plasma from young, healthy donors is a safe and feasible procedure, supporting further investigation into its potential to delay cognitive deterioration through interstitial fluid rejuvenation.
By utilizing a new metric called Distance of Covariance (DISCO), this study demonstrates that human aging is characterized by a systemic increase in entropy that spreads across interconnected organ networks, suggesting that aging is a failure of integrated homeostatic coordination rather than a collection of independent organ-specific processes.
This study utilizes a machine learning approach to analyze medication-related burden and adherence among older patients in Central Nepal, identifying polypharmacy and the need for assistance as key drivers while advocating for targeted clinical interventions like deprescribing.
This study analyzes whole-genome sequencing data to reveal that HSV-1 DNA is less prevalent in individuals with Alzheimer's disease overall, but its association with disease risk is modified by host genetics, specifically showing reduced risk in non-APOE ε4 carriers and increased risk in ε4 carriers.
This study demonstrates that specific AD8 screening items related to judgment, repetition, financial management, tool use, and memory serve as early, multidimensional indicators of physical, psychological, and social vulnerabilities among community-dwelling Chinese-speaking older adults, highlighting the tool's value beyond dementia diagnosis for culturally tailored holistic care.
This retrospective observational study found that while a socially implemented multifactorial intervention program did not significantly delay dementia onset or long-term care certification, it successfully improved cognitive and certain physical functions among participants.
This systematic review of 20 population-based studies in Russia reveals highly variable prevalence estimates for dementia and Parkinson's disease among adults aged 50 and older, largely driven by differences in diagnostic methods and study designs, while highlighting a critical need for standardized, longitudinal research to inform public health planning.
This study utilizes PLS-SEM analysis of 753 urban Chinese empty-nest seniors to validate a multidimensional Aging-Suitability Index, revealing that while safety and physical design form the essential survival foundation, accessibility primarily drives empowerment through perceived independence, thereby guiding prioritized interventions for aging-in-place.